Interleukin-6 in the early assessment of acute pancreatitis.

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Simultaneous serum assays of lipase and interleukin-6 for early diagnosis and prognosis of acute pancreatitis.

BACKGROUND There are no systems for the rapid diagnosis and prognosis of acute pancreatitis in the Emergency Department. Our aim was to evaluate whether the combined use of serum lipase and interleukin-6 or serum lipase and C-reactive protein is able to simultaneously establish both the diagnosis and the prognosis of acute pancreatitis. METHODS Eighty patients with acute abdomen were studied ...

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Interleukin-6: An Early Predictive Marker for Severity of Acute Pancreatitis

BACKGROUND AND AIMS Interleukin (IL)-6, IL-8, IL-10, and C-reactive protein (CRP) have been evaluated for predicting outcomes of acute pancreatitis. However, there is considerable variation in their performance among different studies. We evaluate their accuracy in predicting progression to severe pancreatitis. MATERIALS AND METHODS Serum IL-6, IL-8, IL-10, and CRP levels were measured within...

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Role of interleukin-6 in mediating the acute phase protein response and potential as an early means of severity assessment in acute pancreatitis.

A number of laboratory and clinical studies have shown that interleukin-6 is the principal mediator of the acute phase protein response. In this study the relationship between serum concentrations of interleukin-6 and C-reactive protein in acute pancreatitis are examined and the ability of interleukin-6 to discriminate between severe and mild attacks is assessed. We have studied 24 patients (10...

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Influence of interleukin-1β and interleukin-6 gene polymorphisms on the development of acute pancreatitis.

We investigated the association between 3 main proinflammatory cytokines [interleukin (IL)-1β and IL-6] and the risk of acute pancreatitis. Polymerase chain reaction-restriction fragment length polymorphism was used to genotype IL-1β+3954 C/T (rs1143634) and IL-1β-511 C/T (rs16944) and IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796). The genotype distributions of IL-1β+3954 C/T (rs11436...

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ژورنال

عنوان ژورنال: Gut

سال: 1993

ISSN: 0017-5749

DOI: 10.1136/gut.34.10.1467-b